COVID19 & Research Activities

OVCR Research-Related Updates Regarding COVID19 Emergency and Research Activities

National Cancer Institute (NCI) Central IRB (CIRB)

UIC is a participating site in the National Cancer Institute (NCI) Central IRB (CIRB). NCI CIRB is the IRB of Record responsible for review of the study as well as review of local context issues for participating sites. Local policy, conflict of interest, HIPAA authorization, and ancillary committee approvals are still the responsibility of the relying IRB (UIC).

Through an MOU with Rush Medical Center and Cook County Health (Stroger), UIC OPRS will serve as the  signatory institution and local coordinating center for UIC,  Rush, and Cook County Health for NCI (CIRB) studies.

For research reviewed by NCI, the Cancer Center Protocol Review Committee (CC-PRC) typically provides review of scientific merit, resources and financial aspects of the study.

Local Principal Investigators are responsible for the following:

  • Complete and submit the Annual Investigator Worksheet About Local Context and any other worksheets/forms required by the NCI CIRB for participation.
  • Complete and submit the Study-Specific Worksheet About Local Context to open a study.
  • Provide updates in a timely manner to the NCI CIRB whenever a Signatory Institution Principal Investigator is replaced. The CIRB requires submission and approval of the Annual Principal Investigator Worksheet About Local Context prior to finalizing the replacement Principal Investigator.
  • Incorporating UIC/Rush/Cook County Health -approved boilerplate language into the NCI CIRB-approved model consent form. No changes may be made to either the CIRB-approved or local boilerplate language without prior approval by the NCI CIRB.
  • Revising, monitoring and tracking all consents, assents and short forms as necessary to be in compliance with current CIRB approved protocol.