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Single IRB Review/Reliance

Since January 25, 2018, single IRB review has been mandated for NIH-funded research conducted at more than one site within the United States (Final NIH Policy on the Use of a Single Institutional Review Board for Multi-Site Research). Effective January 20, 2020, the single IRB mandate has been extended to all multi-site research conducted in the U.S. that is supported by funding from any Common Rule agency.

National Institutes of Health (NIH) Grant Application/Contract Proposal Preparation

The NIH requires that the application/proposal for research funding include a plan describing the use of a single IRB that would be selected as the IRB of record for all study sites. The UIC investigator must contact the OPRS Point of Contact (POC) for single IRB (sIRB) review to request a Letter of Support for grant preparation.

The notice will not grant final approval for use of an external IRB, but will serve as a notification of intent to cede IRB review to the reviewing IRB.

UIC cannot guarantee its willingness to rely on a sIRB that has been selected without UIC consultation and approval.