The Office for the Protection of Research Subjects (OPRS)
The Office for the Protection of Research Subjects (OPRS) is the primary coordinating office for the UIC Human Research Protection Program (HRPP). OPRS responsibilities include processing determinations of not human research and exempt research, and provides regulatory guidance and support to the Institutional Review Boards (IRBs) and investigators. In addition, OPRS houses the Federalwide Assurance (FWA) and official IRB rosters. As such, they are responsible for ensuring that the FWA is renewed and that the Office of Human Research Protections (OHRP) is informed of any changes to the FWA, including but not limited to changes in the composition of an IRB or changes in UIC facilities.
What does the IRB do?
1. Ensures the protection of human subjects/participants used in the projects,
2. Provides guidance in the design of experiments to ensure that the information being sought will be obtained in an ethical manner, and
3. Provides a process that assures society that the experimental protocols have been reviewed and approved ethically by knowledgeable individuals who are not directly involved in the research
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Human Research Protection Program
The purpose of the Human Research Protection Program (HRPP) Plan is to describe UIC’s plan to comply with ethical and legal requirements for the conduct and oversight of Human Research.
UIC’s Human Research Protection Program (HRPP) is a comprehensive system to ensure the protection of the rights and welfare of subjects in Human Research. The Human Research Protection Program is based on all individuals in UIC along with key individuals and committees fulfilling their roles and responsibilities described in this plan.
AAHRPP Accreditation Information
The Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP) accreditation is a gold standard recognizing adherence to a rigorous set of human subjects protection standards that go beyond federal and state requirements. It communicates to the public the university’s commitment to the protection of human participants in research and instills trust among our research collaborators.
The accreditation process involves an evaluation of UIC’s Human Research Protection Program (HRPP) and its standard operating procedures as well as the site visit, which is focused on interviews with selected members of the HRPP, including IRB members, Investigators, and research staff.
The UIC Human Research Protection Program (HRPP) was awarded full AAHRPP accreditation in March 2010, and has been AAHRPP accredited since.
University of Illinois Chicago (UIC) Key Information
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University of Illinois Chicago (UIC) FWA & Registration Information
The University of Illinois at Chicago (UIC) holds a Federalwide Assurance (FWA) #00000083 from the Office for Human Research Protections (OHRP) in the Department of Health and Human Services (HHS). This FWA is an agreement between HHS and UIC to review and approve research involving human subjects in accordance with the ethical principles outlined in the Belmont Report and the HHS regulations 45 CFR Part 46. UIC’s Assurance is in effect through May 26, 2028.
In addition, The University of Illinois at Chicago IRB complies with the IRB registration requirements for HHS and the U.S. Food and Drug Administration (FDA). The IRB registration expires on October 18, 2027. The UIC IRB registration information is as follows:
- IRB Organization #: IORG0000080
- University of Illinois at Chicago IRB #1 ID: IRB00000115
- University of Illinois at Chicago IRB #2 ID: IRB00000116
- Chicago Area Institutional Review Board (CHAIRb) ID: IRB00009693
Investigators and sponsors may verify the above information on the Office for Human Research Protections (OHRP) Database for Registered IORGs & IRBs, Approved FWAs, and Documents Received in the Last 60 Days website.
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Compliance regarding Electronic Signatures
The UIC IRB allows electronic signatures to document informed consent as long as the regulatory requirements under 21 CFR parts 11, 50, and 56 for FDA regulated studies and DHHS regulatory requirements under 45 CFR 46 are met. As per 21 CFR 11.100, UIC notified the FDA of its intention to accept electronic signatures as the legally binding equivalent of the traditional hand-written signatures of individuals whose identity the UIC has verified.
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