Version
1.2
Date Updated
Tuesday, May 15, 2012
Descripton

Approved by:  Human Protections Administrator, Director of OPRS, and Executive IRB Chair
AAHRPP REF#: 105
AAHRPP Elements: I.1.F., II.2.D, II.3.A, III.1.C, III.1.D.


POLICY


  1. UIC policy requires that research involving humans undergo review by individuals with relevant scientific or scholarly expertise. Review by individuals with the knowledge to evaluate the rationale, aims, experimental design and methods of the research may occur at several steps in the HSPP review process depending on the research area and level of review, including Departmental Review Committees, Department Heads, and Cancer Center Protocol Review Committee (CC-PRC). Clinical Interface Core (CIC; formerly the Clinical Research Center), Institutional Biosafety Committee, Radiation Safety Committee and Embryonic Stem Cell Research Oversight Committee. Research submitted to the IRB also frequently receives scientific review from external sources, for example NIH study sections and private foundation or professional association review panels. These reviews are considered by the IRB in its scientific evaluation and in making the determination of whether the following regulatory criteria for approval are met:
    1. Risks to participants are minimized by using procedures consistent with sound research design and which do not unnecessarily expose participants to risk.
    2. Risks to participants are reasonable in relation to anticipated benefits, if any, to participants, and the importance of the knowledge that may reasonably be expected to result.
  2. UIC policy does not allow the IRB to delegate its responsibility to judge whether the above criteria for approval are met.
  3. For Department of Defense sponsored research, a substantive amendment to approved research must undergo scientific review prior to IRB review.