The purpose of this program is to bring together, on a cooperative basis, basic and clinical investigators to enhance the effectiveness of their research related to digestive and/or liver diseases and their complications. DDRCCs are meant to improve communication among investigators and to integrate, coordinate, and foster interdisciplinary research involving the etiology, treatment, and prevention of digestive and /or liver diseases. To accomplish this, the DDRCC supports a group of established investigators actively conducting programs of important, high-quality research that relates to a common theme in digestive diseases or liver diseases research. Thus, the purpose of a DDRCC is to provide the capability for accomplishments greater than those that would be possible by individual research project grant support alone.
A DDRCC must be an identifiable unit within a single university medical center or a consortium of cooperating institutions, including an affiliated university. An existing program of excellence as evidenced by productivity and peer-reviewed research funding in the area of digestive and/or liver diseases is a prerequisite before applying. The currently funded research base provides the major support for the investigators, i.e. Center members, who would benefit from a Center's shared resources. The research base includes only currently funded, peer reviewed research grants awarded to the applicant institution/consortium. These may be a mix of Federal and privately funded research awards or research career development awards. There must be sufficient Federal support within the base to fulfill the requirement for a minimum of two federally-funded Center members utilizing each Biomedical Research Core. Training grants, education grants, and fellowship awards are not considered part of the research base funding. Focus, relevance, interrelationships, quality, productivity, and, to some extent, quantity are all considerations in judging the adequacy of the research base.
A DDRCC must have a central research focus or theme. The central focus must be a gastrointestinal/liver disease, group of diseases, or functional studies relating to digestive and/or liver diseases. Examples of gastrointestinal disease-related central focus include, but are not limited to, inflammatory bowel disease, functional bowel disorders, pancreatitis, pediatric gastrointestinal diseases and HIV/AIDS-related gastrointestinal conditions. Examples of liver disease-related central focus include, but are not limited to, liver conditions such as viral hepatitis, nonalcoholic steatohepatitis, immune mediated liver diseases, pediatric liver diseases, and cirrhosis as well as their liver-specific complications. Examples of functional studies appropriate for a central focus include, but are not limited to, gastrointestinal physiology, gastrointestinal mucosal immunology, gastrointestinal motility, actions of gastrointestinal hormones, role of the gastrointestinal tract in obesity, gastrointestinal, liver physiology, and gene therapy for digestive or liver diseases. The theme should be cohesive and well-articulated to ensure a DDRCC with components that will substantially advance a defined area of NIDDK-related science.
The absolute level of research base support must be sufficient to warrant the addition of a Center, typically at least $3 million per year in direct costs. Since "Facilities and Administration" costs vary considerably between institutions, these should not be included in the calculation of the research base. Although collaborations are encouraged, the research base includes ONLY support for the investigators at the applicant institution/consortium.
University is limited to one proposal.
|UIC Letter of Intent||
February 9, 2017
|UIC Internal Competition||
|Sponsor Letter of Intent||
March 14, 2017
Letter of Intent
Depending upon the number of LOIs submitted, OVCR might be required to facilitate an internal peer review process to select UIC’s submission(s) to this program. White paper instructions will distributed to those who have submitted LOIs.
Please contact Natalia Glubisz at RDS@uic.edu or 312-996-8348 with any questions.
If an authorized principal investigator is not listed above, please consider the limited competition still open. Contact RDS@uic.edu for further information.