Internal Competition Completed


Principal Investigators Selected
  • Kent Hoskins, Hematology and Oncology, Medicine

Program Summary

Program Summary

This Funding Opportunity Announcement (FOA) invites applications for Transdisciplinary Collaborative Centers (TCCs) for health disparities research exploring the potential for precision medicine - an emerging approach that takes into account individual variability in genes, environment, and lifestyle - to promote health equity and reduce health disparities. Priorities include: 1) development of new tools and analytic methods for integrating patient data with information about contextual factors acting at the community or population level to influence health; 2) development of pharmacogenomic and other precision medicine tools to identify critical biomarkers for disease progression and drug responses in diverse populations; 3) translation of pharmacogenomic discoveries into effective treatment or clinical practice; and 4) investigation of facilitators and barriers to implementing precision medicine approaches in disadvantaged populations.

 

TCCs supported through this initiative are expected to focus on at least one of the four priority research areas noted above, each combining expertise in precision medicine, population health disparities, and the science of translation, implementation and dissemination to address one or more documented health disparities. The proposed work must focus on one or more health disparities populations, which include Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations and rural populations. Each center will support 2-3 multidisciplinary research projects examining complementary aspects of precision medicine, focusing on interactions between biological, behavioral, and contextual predictors of disease vulnerability, resilience, and response to therapies in patients from disadvantaged communities. For the purposes of this FOA, biological predictors can include but are not limited to genomic, epigenomic, proteomic, metabolomic, and microbiomic variations as well as standard clinical laboratory markers (e.g., blood lipids, inflammatory markers, HbA1c, vitamin D3, etc.), behavioral measures, and other quantitative or qualitative indicators of health status in the study population(s).

 

Applications are expected to demonstrate substantive community input into the identification of research questions to be addressed by the proposed TCC and relevant contextual predictors to be examined in conjunction with biological predictors. For the purpose of this FOA, ‘community’ refers to a group or population that may be defined by geography, race, ethnicity, culture, gender, disease or other health condition, or a common health-related interest or concern. In addition to the required collaborative research projects, each TCC award will support an Administrative Core, a Consortium Core, and an Implementation Core.

 

Application budgets are limited to $1,500,000 in direct costs annually, excluding consortium/contractual costs.  NIMHD intends to fund a total of 3 awards.

Application Limits

Application Limits

UIC is limited to one submission

Additional Information

Deadlines

UIC Letter of Intent
July 8, 2015
UIC Internal Competition
TBD
Sponsor Letter of Intent
August 17, 2015
Sponsor Application
September 17, 2015

Letter of Intent

Letter of Intent

Letter of Intent (LOI) Form

 

Depending upon the number of LOIs submitted, OVCR might be required to facilitate an internal peer review process to select UIC’s submission(s) to this program.  White paper instructions will distributed to those who have submitted LOIs.

 

Please contact Tony Halford at RDS@uic.edu or 6-7036 with any questions.

 

If an authorized principal investigator is not listed above, please consider the limited competition still open. Contact RDS@uic.edu for further information.