This Funding Opportunity Announcement (FOA) will continue to support the program "Cancer Target Discovery and Development” (CTD^2, pronounced cee-tee-dee-squared). CTD^2 is focused on efforts that advance cancer research by bridging the knowledge gap between the rapidly increasing volumes of new data generated by comprehensive molecular characterizations of many cancer types and studies of the underlying etiology of cancer development, progression, and/or metastasis.
The primary purpose of the CTD^2 program is to advance our understanding of cancer etiology, mechanisms and treatment through:
- Improving the understanding of how mutations in cancer genes affect the downstream functions (e.g., gain-of-function, loss-of-function, or neomorphic function) within the protein and cellular pathway(s);
- Searching for new molecular targets with the goal to overcome innate and/or acquired resistance to therapies, particularly clinical resistance related to inter- and intra- tumor heterogeneity; and
- Developing efficient strategies to identify appropriate multiple targets and optimal combination of perturbagens (chemical or biological; immunotherapeutics being a prime example of the latter) with the potential to eliminate all cancer cells, despite their clonal heterogeneity.
This FOA solicits applications for research projects advancing the goals outlined above. The proposed projects should use a combination of state-of-the-art high throughput informatic and experimental approaches to address at a minimum two of these three research areas: (1) characterization and validation of novel cancer targets; (2) identification of molecular markers that can meaningfully predict responses or resistance to anticancer therapies; and (3) development of perturbagens that can affect the proposed targets of cancer treatment.
UIC may submit two applications, provided that each application is scientifically distinct and based on different self-standing project
|UIC Letter of Intent||
July 28, 2016
|UIC Internal Competition||
|Sponsor Letter of Intent||
September 3, 2016
October 3, 2016
Letter of Intent
Depending upon the number of LOIs submitted, OVCR might be required to facilitate an internal peer review process to select UIC’s submission(s) to this program. White paper instructions will distributed to those who have submitted LOIs.
Please contact Tony Halford at RDS@uic.edu or 6-7036 with any questions.
If an authorized principal investigator is not listed above, please consider the limited competition still open. Contact RDS@uic.edu for further information.